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And Q506P), chosen to represent the spectrum of disease-associated PTPN11 mutations. Mutants D61G, E139D, and N308D are found in NS, Y279C is a canonical LS mutation [16,21,42], and Q506P has been reported in both disorders [16], although it is unclear whether this reflects misdiagnosis or true bipotentiality of this allele. The D61G mutation affects the N-SH2 domain, E139D lies within the C-SH2 d