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The major ligand for ClfB in the nares of mice.Role of Loricrin in S. aureus Nasal ColonisationResults ClfB promotes adherence of S. aureus to loricrinClfB is known to bind to the C-terminal ``tail'' region of human and murine K10 which is composed of quasi repeats of Y[GS]nY, sequences which can form omega loops [31,33]. Loricrin, the major component of the CE of squames, is almost entirely compo
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D. Initially a streptomycin resistant (Smr) mutant of S. aureus Newman and ClfB-deficient mutant Newman Smr DclfB (hereafter referred to as Newman and Newman DclfB) were tested for adhesion to immobilized recombinant human and murine loricrin (GST-human loricrin1?15, (Hlor); GST-murine loricrin1?80, (MLor)) and to human and murine K10 peptides (GST-human K10544?63, (HK10); GST-murine K10454?70, (M
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Less potent, K10 adhesin [33]. Complementation of Newman DclfB with pCU1:clfB restored adherence to HLor (Figure S2). These data show that loricrin is a ligand for ClfB. To establish if ClfB alone can promote bacterial adhesion to immobilized loricrin, adhesion assays were performed using L. lactis MG1363 carrying a plasmid that expressed ClfB (pKS80:clfB) [40] and compared to L. lactis carrying t
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Lum stress response pathway in Oikopleura but not human cells (Additional file 1, Figure S5B). It is not clear why Endoplasmic reticulum stress response pathway is responding more in Oikopleura. This pathway can be adaptive, promoting survival or it can lead to induction of apoptosis [39]. However, Apoptosis genes respond equally in both Oikopleura and the human macrophage cells (Additional file 1
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R-activated receptor alpha (PPARa) regulates CYP4A [11-14]. SXR and CAR are closely related nuclear receptors (NR1I) that are activated by a wide range of compounds including several clinically used drugs [15]. AhR is a major xenobioticsensing receptor that is activated by environmental pollutants such as dioxin and PAHs including benzo[a]pyrene (BaP) [16,17]. AhR and its dimerization partner AhR
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Sation. Br J Psychiatry 2001;178:207-15. 7. Wolff G, Pathare S, Craig TSation. Br J Psychiatry 2001;178:207-15. 7. Wolff G, Pathare S, Craig T et al. Public education for community care: a new approach. Br J Psychiatry 1996; 168:441-7.The power of stigmaJUAN J. L EZ-IBOR JR.Department of Psychiatry, Complutense University, L ez-Ibor Clinic, Nueva Zelanda 44, 28035 Madrid, SpainStigma is a ve
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Fault settings. In the top ranking networks appear genes that are also part of the enriched pathways and processes (Table 3A and 3B, Additionalfile 7). For example many stress response genes including those involved in the GO Biological Process "endoplasmic reticulum unfolded protein response" are represented in the third ranking network (Additional file 1, Figure S4).Comparison of BaP induced res
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Iomedcentral.com/1471-2164/13/Page 8 ofFigure 4 AP-1 centered network of BaP-regulated genes sets. MetaCore Transcription Regulation algorithm with default settings was used for generation of biological networks. For clarity, only genes with direct connections with AP-1 and marked by the GO Process terms "Response to Stress" and "Response to Chemical Stimulus" are shown. The network objects were r